It will be the first high-level interaction between the two countries since Chinese Vice-President Han Zheng attended Trump's inauguration in January.
Mr Bessent said he looked forward to rebalancing the international economic system to better serve the interests of the US.
"My sense is that this will be about de-escalation, not about the big trade deal, but we've got to de-escalate before we can move forward," he said in an interview with Fox News.
"If the United States wants to resolve the issue through negotiations, it must face up to the serious negative impact of unilateral tariff measures on itself and the world," a Chinese commerce ministry spokesperson said on Wednesday morning.
Chinese state media reported that Beijing had decided to engage with the US after fully considering global expectations, the country's interests and appeals from American businesses.
The report added that China is open to talks but reiterated that if the country decides to continue to fight this trade war – it will fight to the end.
The trade war has triggered turmoil in financial markets and sent shockwaves across global trade.
